Microarray, ChiP-qPCR and Chip-seq analysis confirmed the on-target effect of the Omomyc mini-protein: it shuts down both transcriptional programs driven by Myc and gene signatures associated with poor prognosis in lung cancer, without affecting gene sets for other bHLHLZ transcription factors involved in the physiopathology of the disease. The gene discussed is MYC; the disease is lung cancer.