Treatment of H1299, A549 and H1975 NSCLC cells with the Omomyc mini-protein in culture caused a reduction in total cell number in a dose-dependent manner, with 50% inhibitory concentrations (IC50s) in the low micromolar range, more effectively than in Myc-independent SH-EP neuroblastoma cells, recapitulating the effect of an siRNA against MYC. Here, MYC is linked to non-small cell lung carcinoma.