CXCR4 and nonpapillary renal cell carcinoma: In Figure 1, the CXCR4 mRNA levels in different tumors are investigated by public gene expression, with higher CXCR4 expression being shown in hematological malignancies, such as acute myeloid leukemia (AML) and diffuse large B-Cell lymphoma (DLBCL), followed by thymoma, clear cell renal cell carcinoma (ccRCC), and adrenocortical carcinoma (Figure 1a).