The prognostic role of CXCR4 was confirmed in a recent meta-analysis, including a total of 11 relevant articles involving 1439 pancreatic ductal adenocarcinoma (PDAC) patients, indicating CXCR4 as a negative prognostic marker associated with the risk of lymph node involvement and distant metastasis [56]. Here, CXCR4 is linked to pancreatic ductal adenocarcinoma.