Consistent with this, mice carrying CXCR4WHIM-like mutations show defective B-cell development [120], and a minority of WHIM patients show increased susceptibility to Epstein–Barr virus (EBV)-related B-cell lymphoproliferative disorders and B-cell lymphomas [121], further demonstrating that CXCR4 signaling is essential for proper B-cell functionality. This evidence concerns the gene CXCR4 and B-cell non-Hodgkin lymphoma.