Moreover, similarly to LPL/WM, data in literature showed that a substantial proportion of activated B-cell-like subtype DLBCL (ABC DLBCL) also carry the MYD88L265P mutation, whereas mutations in other small B-cell lymphomas are rare [87,96,97], suggesting that MYD88/CXCR4 interplay could represent a crucial hub in B-nHL malignancies. Here, CXCR4 is linked to diffuse large B-cell lymphoma.