Demethylation of histones H3K9 (Histone H3 Lysine 9) and H3K36 (Histone H3 Lysine 36) activates the transcription of pro-inflammatory genes and oncogenes in vivo Granulocyte/Macrophage Colony Stimulating Factor (GM-GSF), Macrophage Colony-Stimulating Factor (M-CSF), InterLeukin 6 (IL-6), c-Myc, Tumor Necrosis Factor alpha (TNF-alpha) in colitis-associated cancer mouse models. This evidence concerns the gene TNF and cancer.