CXCR4 and cancer: Data from approximately 19,000 patients genomically profiled across multiple cancer types at 8 academic medical centers showed that the genomic alteration rate (including mutation, copy number, and rearrangement) of the CXCR4 gene is 0.30%, accounting for 0.24% genetic loss, 0.03% CXCR4 non-sense (NS), 0.01% CXCR4 frame-shift (FS), and 0.01% CXCR4R334X [76].