However, although an altered expression of CXCR4 has been reported for several cancer types (Figure 1), a significant frequency of CXCR4 mutated variants has been detected in only two cancer types—the uterine corpus endometrial carcinoma (uterine cancer, UCEC), which is the fourth most common cancer in females and accounts for approximately 80% of endometrial adenocarcinomas, and the DLBCL, the most common aggressive form of B-cell NHL (Table 1, Figure 2 and Figure 3). This evidence concerns the gene CXCR4 and endometrium adenocarcinoma.