Interestingly, Bagratuni et al. identified peripheral blood cell-free DNA as a useful, minimally invasive, cost-effective, and time-effective tool for the identification of the presence of both MYD88 and CXCR4 mutations in patients with IgM monoclonal gammopathies, avoiding unnecessary BM assessment [172]. This evidence concerns the gene MYD88 and monoclonal gammopathy.