However, although an altered expression of CXCR4 has been reported for several cancer types (Figure 1), a significant frequency of CXCR4 mutated variants has been detected in only two cancer types—the uterine corpus endometrial carcinoma (uterine cancer, UCEC), which is the fourth most common cancer in females and accounts for approximately 80% of endometrial adenocarcinomas, and the DLBCL, the most common aggressive form of B-cell NHL (Table 1, Figure 2 and Figure 3). The gene discussed is CXCR4; the disease is uterine corpus endometrial carcinoma.