LEP and obesity due to melanocortin 4 receptor deficiency: The molecular mechanism of obesity mediated by cytokines, adiponectin, and leptin has been correlated with increasing inflammation and oxidative stress, and leads to the development of metabolic diseases including certain types of cancer; hyperglycemia; type 2 diabetes; high blood pressure; and liver, heart, and gallbladder diseases [2,7]; which pose major health risks globally [8].