PPARG and obesity due to melanocortin 4 receptor deficiency: Since adiponectin is regulated by the peroxisome proliferator-activated receptor-γ (PPARγ) pathway and is involved in close-inhibition relationships with inflammatory cytokines [99], the dysregulation of the nuclear receptor peroxisome proliferator-activated receptor δ/β (PPARδ/β) could be associated with obesity, because of its key role in lipid metabolism [131].