Furthermore, the results from the TM-(–)-18 and TM-(–)-4a treatments showed a decrease in Mcl-1 and Bcl-2 protein levels in primary lung cancer cells (Figure 4c,d), but as we previously discussed in the section about the RT-treatment conditions, Mcl-1 depletion was the main mechanism by which these compounds induced apoptosis. This evidence concerns the gene BCL2 and lung cancer.