Consequently, it is not unexpected that the amplification and overexpression of pro-survival Bcl-2 proteins, such as Bcl-2 and Mcl-1, are found in many cancer types (e.g., non-small-cell lung cancer, breast cancer, ovarian cancer, prostate cancer, and pancreatic cancer) [9,10,11]. Here, BCL2 is linked to familial pancreatic carcinoma.