PTGS2 and asthma: In a murine asthma model, anthocyanins (Medox, 150 mg/kg or 300 mg/kg) produced anti-inflammatory effects by downregulation of pro-inflammatory cytokines and cyclooxygenase-2 (COX-2), a key enzyme responsible for generating prostanoids (including prostaglandin E2), and the effect was associated with the dose of anthocyanins, suggesting a dose–response relationship [68].