MYB and cyclic hematopoiesis: For example, miR-150 was found to function as a tumor suppressor in CN by targeting c-Myb [38]; overexpression of miR-122 could lead to the development of CN liver metastasis [39]; expression of miR-199a-3p (pre-miRNA of miR-199a) could be involved in the development, tumorigenesis and progression of CN [40].