The tyrosine kinase receptor phosphatase Src homology 2-containing phosphotyrosine phosphatase (Shp2) is likely involved in this dual regulation of ERK and Akt by FSH, and disruption of this pathway in Shp2 knock-out mice leads to infertility because of abnormalities in the blood–testis barrier and premature exhaustion of the germ cell population [63]. Here, PTPN11 is linked to Infertility.