BRD2 and male infertility: Although the full restoration of normal semen parameters is generally not achieved in HH men (depending on HH causes) [4] and not even necessary to obtain a pregnancy, gonadotropin treatment is sufficient to stimulate spermatogenesis [1] and provides a rationale for using, even if empirically, FSH, with or without hCG, in male idiopathic infertility, which is considered a form of “functional” hypogonadism.