NFKBIA and gastritis: In addition, the phosphorylation of IκBα was inhibited by Rb-ME in peritoneal macrophages that were derived from LPS-induced peritonitis mice and in HCl/EtOH-triggered gastritis mice (Figure 4E,F), which suggested that Rb-ME exhibits an anti-inflammatory effect by participating in the regulation of NF-κB signaling.