In summary, we have replicated the association of seven SNPs and quantitative traits of T2D among the Chinese population, of which 5q11.2-rs4432842, RASGRP1-rs7403531, and SEC16B-rs574367 were associated with increased insulin resistance, MAEA-rs6815464 was associated with decreased insulin resistance, and ANK1- rs516946, CENTD2-rs1552224, and TSPAN8-rs7961581 were associated with increased impaired insulin release. Here, SEC16B is linked to Insulin resistance.