SEC16B and Insulin resistance: As shown in Table 2 and Figure 1, three SNPs were associated with increased insulin resistance risk with adjusting for covariates, including 5q11.2-rs4432842 (OR = 1.23, 95% CI: 1.04–1.45), RASGRP1-rs7403531 (OR = 1.35, 95% CI: 1.13–1.62), SEC16B-rs574367 (OR = 1.34, 95% CI: 1.07–1.67).