Our result of high PD-L1 expression in AC, NOS is in line with data from Mukaigawa et al. who reported PD-L1 expression (1% cutoff, clone E1L3N) in 36% of AC, NOS but only in rare cases of AdCC (2%), MEC (9%), and ACC (0%) [22]. The gene discussed is CD274; the disease is adrenocortical carcinoma, hereditary.