PAEP and leukemia: Table 3 showed the top 10 upregulated genes including REN, PAEP, TRIM67, EGR1, ACRBP, DLX2, VASN, SQSTM1, CATSPER1, and NTRK1. Among these genes, early growth response 1 (EGR1), a transcriptional regulator, has been reported to promote megakaryocytic and myeloid differentiation and to suppress leukemia tumorigenesis [32,33].