RORC and cancer: Moreover, one recently published study demonstrated that cholesterol biosynthesis is essential for breast cancer stem cell propagation [77], whereas another showed that the hyper-activated cholesterol biosynthesis program of TNBC is regulated by nuclear receptor RORγ (RAR-related orphan receptor gamma), whose inhibition by receptor antagonists leads to tumor regression in patient-derived xenografts and immune-intact models [78], confirming the extreme importance of cholesterol biosynthesis in TNBC cancer progression.