TEK and neoplasm: Accordingly, in MCF-7 TIE2tet cells, induction of the expression of TIE2 with Dox-induced a significant increase of the cyclin-dependent kinase (CDK) inhibitors CDKN1A (or P21CIP1) and CDKN1B (or P27KIP1) (Figure 5C), as previously reported in dormant tumor cells [39].