These results correlate with a decrease in the expression of the proliferation markers MKI67 and PCNA when MCF-7 TIE2tet expressed TIE2, as well as an increase of the markers of cell cycle arrest CDKN1A and CDKN1B, already found to be increased during BMP7-induced dormancy in PCa cells [45]. Here, CDKN1A is linked to posterior cortical atrophy.