JAG1 and posterior cortical atrophy: Subsequently, factors from the microenvironment such as osteoblast-derived Bone Morphogenetic Protein 7 (BMP7) and Growth Arrest Specific 6 (GAS6) will induce the dormancy of PCa cells, while osteoblast-derived Jagged 1 (JAG1) and hypoxia induce the dormancy of BCa cells [11,12,13,14].