SMARCB1 and rhabdoid tumor: Previous studies in malignant rhabdoid tumor (MRT) have shown that the loss of SWI/SNF complex subunits, such as SMARCB1/SNF5, result in an up‐regulation and dependency upon an opposing chromatin remodeling complex, the polycomb repressive complex 2 (PRC2).13, 14, 15, 16 Both cell lines exhibited extremely low levels of SMARCB1 gene mRNA expression, relative to primary renal proximal tubule epithelial cells (RPTEC), and no detectable levels of SMARCB1/SNF5 protein by western blot analysis (Figure 3A,B).