NGLY1 and scoliosis: Scoliosis, which is one of the characteristics of NGLY1 deficiency subjects (6–9,13), was also observed in older Ngly1−/− rats at 29 weeks of age (Supplementary Material, Fig. S3C and D), but not at 5 and 15 weeks of age, although the penetrance was not high, and there was a sex difference in the penetrance (male, 6/10 rats; female, 2/10 rats).