The results are in accord with the majority of previous observational studies (6, 7, 8, 9, 10, 11, 12, 13), and are also supported by findings from the Hypertension in the Very Elderly (HYVET) trial, which found a lower rate of fractures in older people with hypertension treated with thiazides and ACE inhibitors (16), but differ from a post-hoc analysis of the Antihypertensive and Lipid Lowering to prevent Heart Attack (ALLHAT) trial, where ACEi did not confer a lower risk of fracture compared to calcium channel blockers, and were inferior to thiazides (17). This evidence concerns the gene ACE and Hypertension.