SOD1 and familial amyotrophic lateral sclerosis: Although this HECW1‐mutant SOD1‐TRAPδ complex promotes degradation of mutant SOD1, these proteins tend to form the neuronal Lewy body‐like hyaline inclusion, which is a hallmark of the disease severity of familial amyotrophic lateral sclerosis.72, 114 Indeed, certain proteins that are essential for normal cellular functions are sequestrated in the protein aggregates.