Based on the biochemical evidence, PTEN and p53 interact with NEDD4, WWP1, WWP2, and HECW1, and the binding has been shown to be involved in neuronal cell death and diseases.72, 106, 113, 114 These findings suggest that alterations of WW domain‐containing E3 ligases in binding and signaling may contribute to the development of cancers and neurodegenerative disease. Here, PTEN is linked to cancer.