WWP2 and neoplasm: For example, WWP1 has been found amplified in numerous tumors, while downregulation of WWP1 attenuates leukemic cell growth.140 Similar to WWP1, a small‐molecule inhibitor of WWP2 has been investigated and might have an anti‐tumor function.141 Furthermore, enhancing or disruption of the protein‐protein interactions between WW domain‐containing E3 and its substrate is a novel strategy to treat cancers and diseases.