PTEN and Familial prostate cancer: Similar to prostate cancer, increased expression of NEDD4 and reduced expression of PTEN have been reported in non‐small‐cell lung carcinomas, further suggesting the role of NEDD4 in promoting PTEN degradation and tumorigenesis.77 A recent study reported that the adaptor protein Numb mediates the interaction between NEDD4 and PTEN.