TP53 and cancer: Supporting evidence reveals that tumor suppressors p53 and PTEN might have a role in the disease progression.128, 129, 130, 131 Albeit loss of PTEN expression contributes to cancer progression, inhibition of PTEN rescues the normal synaptic function and cognition in animal model.128 As a gatekeeper, p53 controls cell cycle progression, DNA damage response, and tissue development.