EGR2 and neoplasm: Ectopically expressed WWP2 decreases Notch3 signaling and results in the cell cycle arrest and reduced tumor volume in an ovarian cancer xenograft model.90 WWP2 is also involved in attenuating the activation‐induced death of T cells.91 WWP2 binds EGR2 through its WW domains and PY motif in EGR2 to promote EGR2 ubiquitination and degradation, thereby reducing EGR2‐induced Fas ligand expression after T cell activation (Figure 5B).