WWOX and skin neoplasm: For example, when tumor suppressor WWOX is optimally activated, the resulting pY33‐WWOX plays a homeostatic role in maintaining normal physiology and restricts tumor growth.64 During the hyperplasia stage of skin cancer development, pY33‐WWOX levels are increased in vivo.65 The raised pY33‐WWOX levels are intended to halt cancer growth.