Binding of NEDD4L with Dvl2 leads to suppression of Wnt/Dvl2 signaling and inhibition of colorectal cancer growth.50 NEDD4L downregulation is frequently found in tumors, and this correlates with tumor progression.51 Thus, control of protein degradation is important for regulating the cellular response to stimuli, especially for TGF‐β/Smads. Here, NEDD4L is linked to neoplasm.