TNFSF11 and osteonecrosis: Elevated UPR has been associated with increased osteoclasts and bone loss in a rats with osteonecrosis of the femoral head,67 mice with periodontitis induced by in P gingivalis,68 as well as mouse models of hind limb unloading and particle‐induced osteolysis.69, 70 Notably, the latter two models also reported an increase in RANKL in whole bone extracts.