This includes the modeling of bone as a reservoir of latent TGF‐β that is released and activated during tumor‐induced osteolysis, which in turn impacts the osteoblast:osteoclast balance in the remodeling unit.56 In addition, the role of cancer‐associated fibroblasts57 and immune cells58 in tumor cell metastasis has been modeled, which is of particular interest given the diverse cellular environment of the bone metastatic niche. Here, TGFB1 is linked to neoplasm.