More recently, very early ART (initiated within 40 days of the estimated date of infection) in Fiebig I-II acutely infected patients was demonstrated to be associated with a significant increase in CD4/CD8 ratios [14], and the 1-year longitudinal evaluation of 83 patients starting ART within 120 days after the estimated date of infection displayed a better reconstitution of CD4/CD8 ratio compared to chronically infected subjects [15]. This evidence concerns the gene CD8A and infection.