Some of the proteins identified as playing an important role in development of T2DM is glucokinase, AMP-activated protein kinase, 11 β-hydroxysteroid dehydrogenase, insulin receptor substrate, interleukin 1 beta, dipeptidyl peptidase IV, C-reactive protein, glutamine fructose-6-phosphate amidotransferase, peroxisome proliferator activated receptor gamma, protein tyrosine phosphatases, tyrosine kinase insulin receptor, protein kinase B and insulin receptor. Here, INSR is linked to type 2 diabetes mellitus.