The significantly downregulated expression level of Mmp10 and plasma Mmp3 by WOL intervention could help prevent the degradation of a broad range of extracellular components including proteoglycans, type II, type IV, type IX and type XI collagens, laminin, and fibronectin63, thereby inhibiting the degradation of the mucosal wall that is manifested in IBD patients66. The gene discussed is MMP10; the disease is inflammatory bowel disease.