Overexpression of SND1, either in HCC cell lines or in Alb/SND1 mice, resulted in marked activation of NF-κB, and Alb/SND1 mice presented with increased levels of pro-inflammatory cytokines, such as IL-6 and TNFα, thereby providing a link between SND1 and inflammation[40,43]. The gene discussed is IL6; the disease is hepatocellular carcinoma.