Moreover, multiple studies have demonstrated that high SIX1 expression leads to poor survival in a variety of cancers.23, 24, 25 In our concurrent study, in cultured melanoma cells, SIX1 was proven to promote cell proliferation and invasion, and SIX1 expression could be inhibited by miR-150-5p, which exhibited inhibitory functions in melanoma cell.26 Here, SIX1 is linked to cancer.