Guided by a transcriptome and comprehensive metabolite analysis we recently made a couple of intriguing observations that following treatment with the MET inhibitor, crizotinib, glioblastoma cells showed evidence of metabolic reprogramming, rendering them sensitive to combination treatments, involving inhibitors of FAO (etomoxir) and OXPHOS (metformin and oligomycin) along with crizotinib (Figure 1). Here, MET is linked to glioblastoma.