Consistently, chromatin-immunoprecipitation revealed that CREB bound the promoter region of PGC1α and blocking of CREB interfered with PGC1α expression and its effect on respiration in tumor cells.In summary, our findings position metabolic reprogramming by c-MET inhibition as a targetable vulnerability for one of the most recalcitrant solid malignancy, the primary brain tumor glioblastoma. The gene discussed is CREB1; the disease is neoplasm.