Tert-butyl-4-(2-hydroxyethyl)-4-(pyrrolidin-1-yl)-piperidine-1-carboxylate (PYPEP), which is another PPARδ agonist, inhibited atherosclerosis in human apolipoprotein B100 and cholesteryl ester transfer protein double-transgenic mice by improving the serum lipoprotein profiles [34]. Here, PPARD is linked to atherosclerosis.