In our study, the expression of CCR2, which is a macrophage-presenting marker involved in the onset of atherosclerosis and NAFLD, was significantly lower in the spleen tissues from aspirin-administered rabbits; however, the expression of mannose receptor, which represents an anti-inflammatory phenotype of macrophages, was markedly elevated in the spleen tissues from aspirin-administered rabbits. This evidence concerns the gene CCR2 and atherosclerosis.