APOE and metabolic dysfunction-associated steatotic liver disease: Furthermore, the anti-NAFLD effects of dioscin and chicory (Cichorium intybus L.)polysaccharides were dependent to AMPK [35, 36], and in ApoE knock-out mice, AMPK activation by agonists decreased the formation of atheromata-inducing macrophages, but it increased the antiatherogenic effects of HDL-cholesterol [37, 38].