TP53 and adenoma: When adenoma is compared with the healthy tissue, we found that six genes increased between onefold and twofold: MMP1, MMP7, WNT5A, MYC, AXIN2, and TLR4, while six genes increased between 0.5-fold and onefold: MSH2, TP53, NOS2, CCND2, BAX, and PTGER2. The downregulated genes include IL-6R, TLR3, ARRB1, and TLR7.