AXIN2 and colorectal carcinoma: MYC, WNT-5A, and AXIN2 were shown to be upregulated in HPV-positive CRC tissues when compared to HPV-negative tissues, while MMP7 was shown to be downregulated in HPV-positive CRC tissues when compared to HPV negative tissues, but the difference did not reach the level of statistical significance (P > 0.05) (Figure 5).