To expand the sample size, the TCGA database was exploited to search the DEGs with significantly different expression in CRC and non-CRC tissues; combining with the DEGs from our microarray analysis, we found that MMP7, WNT5A, MYC, and AXIN2 genes upregulated in tumor vs. healthy tissues, adenoma vs. healthy tissue in TCGA; these genes were overlapped between the TaqMan Array Plates data and TCGA data. The gene discussed is AXIN2; the disease is colorectal carcinoma.