The DEGs in HPV-positive tissues were involved in signaling pathways including activators of Wnt/β-catenin, phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), mammalian target of rapamycin (mTOR) signaling, and inhibitors of TGFβ and TP53 signaling, which were also the most frequent changes in CRC progression. Here, WNK2 is linked to colorectal carcinoma.