PIK3CA and colorectal carcinoma: The DEGs in HPV-positive tissues were involved in signaling pathways including activators of Wnt/β-catenin, phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), mammalian target of rapamycin (mTOR) signaling, and inhibitors of TGFβ and TP53 signaling, which were also the most frequent changes in CRC progression.