Indeed, dysregulation of the barrier is associated with the increased production of IL-23 [92] and the induction of proinflammatory cytokines, including IL-17 that generates a proinflammatory microenvironment recruiting tumor-infiltrating immune cells (i.e., tumor-infiltrating lymphocytes, TILs) [6, 7, 51]. The gene discussed is IL17A; the disease is neoplasm.