IFNG and autoimmune thrombocytopenic purpura: Researches have shown that the TIMP-3 protein has a statistically positive correlation with IL-4 and platelet count, but a negative correlation with IFN-γ in ITP patients, suggesting that this protein may lead to Th1/Th2 polarization via affected antigen-presenting cells and contribute to the occurrence and development of autoimmune disease [20].