Our GWAS results showed that GBE1 was significantly associated with ITP (P = 6.45 × 10−9), and the TaqMan probe genotyping results also showed that the MAF of rs117503120 in ITP cases was significantly lower than controls, suggesting that the rs117503120 minor allele may be protective for ITP. Here, GBE1 is linked to autoimmune thrombocytopenic purpura.