CD8A and melanoma: CD8+ T cells are major actors of anti-cancer immunity; their infiltration in TME has been reported to correlate with better prognosis in several malignancies such as melanoma, ovarian, pancreatic, breast and colorectal cancers (Fukunaga et al., 2004; Sato et al., 2005; Neagu, 2012; Ziai et al., 2018).