Finally, an early onset Parkinson’s Disease (PD) mutation in VPS35 (D620N) was shown to compromise the interaction between the WASH complex and retromer, and to impair endosomal trafficking as well as autophagy (Vilarino-Guell et al., 2011; Zimprich et al., 2011; Follett et al., 2014; McGough et al., 2014; Miura et al., 2014; Zavodszky et al., 2014). The gene discussed is VPS35; the disease is Parkinson disease.