Genomic factors include tumor immunogenicity, mutation/neoantigen-load (Snyder et al., 2014), increased TMB (Keenan et al., 2019), increased PD-L1 level (Havel et al., 2019), interferon gamma (FNγ) response (Ayers et al., 2017), human leukocyte antigen (HLA) diversity, deficient DNA mismatch repair (dMMR) (Zhao et al., 2019), high microsatellite instability (MSI-hi), copy-number alterations, checkpoint regulators e.g., CMTM4/6 (Mezzadra et al., 2017), up-regulation of checkpoint receptors and oncogenic signaling (Havel et al., 2019; Keenan et al., 2019). This evidence concerns the gene IFNG and neoplasm.