In a metastatic mouse mammary tumor model (MMTV-PyMT), Schmittnaegel et al. (2017) could show that a dual inhibition of both angiogenic factors resulted in an increase of tumor antigen presentation, activation of tumor-infiltrating CD8 + T cells, and induction of endothelial PD-L1 expression through IFNγ. The gene discussed is CD274; the disease is neoplasm.