Various miRNAs such as miR-34a, miR-17-5p, miR-15b, miR-193a-3p, miR-197miR-200c showed correlation with expression of PD-L1 in tumor tissues as well as in sera or plasmas, and purposed to have predictive values in ICBs therapy of different cancers (Chen et al., 2014; Cortez et al., 2016; Ahn et al., 2017; Audrito et al., 2017; Kao et al., 2017; Fan et al., 2019). The gene discussed is CD274; the disease is cancer.