CD274 and breast cancer: Moreover, developing strategies on combining different ICBs are appealing in breast cancer treatment, such as combining anti-PD-1/PD-L1 with anti-cytotoxic T-lymphocyte associated protein-4 (anti-CTLA-4) (Wolchok et al., 2017) or other co-inhibitory molecules (Chester et al., 2018; Harding et al., 2019).