RNAi experiments in multiple human glioblastoma cell lines revealed synemin enhances the migratory properties of astrocytoma cells and plays a role in enhancing glioblastoma cell proliferation through its effects on the PI3K-Akt signaling pathway (Pan et al., 2008; Pitre et al., 2012). Here, SYNM is linked to astrocytoma (excluding glioblastoma).