Another transcriptomics based assessment is the 18-gene, tumor inflammation signature (TIS: TIGIT, CD27, CD8A, PD-L2, LAG3, PDL-1, CXCR6, CMKLR1, NKG7, CCL5, PSMB10, IDO1, CXCL9, HLA.DQA1, CD276, STAT1, HLA.DRB1, and HLA), which uses NanoString nCounter to measure intra-tumoral adaptive immune responses. Here, CD274 is linked to neoplasm.