In addition, TGF-β can induce renal fibrosis by transactivating epidermal growth factor receptor (EGFR) and p53 via proto-oncogene tyrosine-protein kinase Src (c-Src) and ROS-dependent mechanisms (Samarakoon et al., 2013; Harskamp et al., 2016). Here, TGFB1 is linked to renal fibrosis.