In addition, juglone has also shown to reduce the prostate cancer cell growth by inhibiting PIN1 activity (Hennig et al., 1998; Chao et al., 2001; Jeong et al., 2009; Costantino et al., 2016; Wang et al., 2017; Shin et al., 2018). This evidence concerns the gene PIN1 and Familial prostate cancer.