On the contrary, PIN1 induces the degradation of tumor suppressors such as Daxx, FoxO4, Fbw7, GRK2, PML, KLF10, RARa, RUNX3, RBBP8, Smad, SUV39H1, SMRT, and TRF1 (Lu and Zhou, 2007; Lee T. H. etal., 2009; Ryo et al., 2009; de Thé et al., 2012; Lu and Hunter, 2014; Ueberham et al., 2014; Wei et al., 2015). Here, PIN1 is linked to neoplasm.