Furthermore, PIN1 inhibition by API-1 and TAB29 upregulates miRNA biogenesis by maintaining the active XPO5 conformation and represses the development of hepatocellular carcinoma (HCC), suggesting that PIN1 mediates miRNA biogenesis mechanism, API-1 can be a drug candidate for therapy for Pin1-overexpressing or extracellular signal-regulated kinase-activated HCC (Pu et al., 2018; Fan et al., 2019). This evidence concerns the gene XPO5 and hepatocellular carcinoma.