Especially compound 9a, one of the artemisinin derivatives increases anti-proliferative, pro-apoptotic and anti-metastatic effect in PC-3 prostate cancer cells by decreasing the expression of Pin1, cyclin D1, c-Myc, elF4E, and PCNA (Gour et al., 2019). This evidence concerns the gene CCND1 and Familial prostate cancer.