PIN1 is associated with the development of various cancers, including melanoma, breast cancer, gastric cancer, cervical cancer, gallbladder cancer, pancreatic ductal carcinoma, colorectal cancer, prostate cancer, ovarian cancer, non-small cell lung cancer, osteosarcoma, esophageal cancer, hepatitis B virus (HBV)-induced hepatocellular carcinoma, Burkitt lymphoma, and T cell acute lymphoblastic leukemia. This evidence concerns the gene PIN1 and osteosarcoma.