MECP2 and myocardial infarction: Feng et al. (2014) demonstrated that BMSC-derived exosomes could mediate the transfer of highly expressed miR-22 in the condition of ischemic preconditioning (IPC) from BMSCs into cardiomyocytes, leading to reduced apoptosis and cardiac fibrosis after myocardial infarction by downregulating the expression level of target Mecp2. Shao et al. (2017) compared the efficiency of bone marrow-derived MSCs and MSC-Exo in myocardial infarction recovery for the first time.