In subsequent animal experiments, MSNs@PCM@TP + 808 nm laser increased the mRNA and protein levels of PTPN22 in the thymus and spleen in the RA rats, while it decreased the protein levels of IL-2, IL-6 and TNF-α in RA rat serum, thereby achieving the objective of inhibiting the over activated immune system. This evidence concerns the gene IL2 and rheumatoid arthritis.