Hypermethylation of ADAMTS6 is identified in multiple cancers (Kordowski et al., 2018), and its methylation level continuously decreased in mCHG (Figure 7A), while LMX1A continuously increased in mCHG and serve as a DNA methylation marker in cervical cancer (Lai et al., 2008). The gene discussed is ADAMTS6; the disease is cervical cancer.