B10 cells, a small subset of CD19+CD24hiCD38hi B cells as well as CD19+CD1dhiCD5hi B cells in mice, are an immunosuppressive B cell type that stop the expansion of pathogenic, proinflammatory lymphocytes and play a significant role in suppressing autoimmune responses and preventing autoimmunity through the secretion of IL-10, IL-35, and transforming growth factor β (TGF-β) (31). The gene discussed is TGFB1; the disease is Autoimmunity.