CHEK1 and neoplasm: For example, Pan et al. (37) reported that CELSR3 may be a promising prognostic gene in head and neck squamous cell carcinoma; He et al. (38) demonstrated that GPSM2 facilitated tumor growth and metastasis; CHEK1 downregulation suppressed by hsa-mir-195-5p hindered growth and metastasis of non-small cell lung cancer (39).