By performing survival (OS and RFS) analysis using TCGA hepatocellular carcinoma data, nine genes including three novel genes (CELSR3, GPSM2 and CHEK1) and six “known” genes [CLEC3B (26), DNASE1L3 (27), PTTG1 (28, 29), KIF2C (30), XPO5 (31, 32) and UBE2S (33, 34)] were identified as prognosis-associated genes in hepatocellular carcinoma. The gene discussed is DNASE1L3; the disease is hepatocellular carcinoma.