IL6 and breast carcinoma: It has previously been shown that these elevated circulating cytokines (i.e., IL-6 and IL-8) exerted effects at distant sites (47, 48), this favors the progression of breast cancer by upregulating the secretion of pro-inflammatory adipokines as well as exacerbates immune cell infiltration, which in turn promoted cancer progression through cellular proliferation, angiogenesis and the inhibition of apoptosis (38, 39, 49).