It has previously been shown that these elevated circulating cytokines (i.e., IL-6 and IL-8) exerted effects at distant sites (47, 48), this favors the progression of breast cancer by upregulating the secretion of pro-inflammatory adipokines as well as exacerbates immune cell infiltration, which in turn promoted cancer progression through cellular proliferation, angiogenesis and the inhibition of apoptosis (38, 39, 49). This evidence concerns the gene IL6 and breast cancer.