LIPE and colorectal cancer: Recently, Ebadi et al. (92), showed that chemotherapy treatment (5-fluorouracil and Irinotecan) in a colorectal cancer model diminished peri-uterine adipose tissues' function to store lipids by significantly downregulating the expression of ACC, FAS, and HSL, as well as markers of β-oxidation (i.e., CPT-2), compared to treatment-naïve rats.