TNFRSF1A and central nervous system cancer: More importantly, the expression level of TNFRSF1A was positively associated with WHO grade in the eight datasets, including GSE4290, GSE68848, CGGA (mRNA-array_301, mRNAseq_325 and mRNAseq_693), TCGA_glioma, GSE4271 and GSE4412, respectively (Figures 3I–P).