SLC16A1 and cancer: Occurrence of this “two compartment model” was additionally described between lactate-avid breast cancer cells and “corruptible” glycolytic cancer-associated fibroblasts (CAF) by Lisantis's group (85), and further amplified to a “three compartment model” in the study by Curry et al. (86); in head and neck cancer samples, the authors showed that catabolic compartments composed of Warburg-adapted MCT4-expressing cancer cells and CAFs provided anabolic MCT1-expressing cancer cells with glycolysis-originating lactate (86).