FGF2 and cancer: Several mechanisms have been pointed out as mediators of those metabolic affairs, such as secretion of growth factors [e.g., cancer cell-secreted basic fibroblast growth factor (bFGF) in response to CAF-secreted hepatocyte growth factor (HGF) (92)], interleukins [e.g., IL-1β secretion by cancer cells (93)], and exosomal microRNAs (94).