Prior individual studies examining changes in BNP as a predictor of stress test-induced myocardial ischemia were underpowered to make definitive conclusions and have findings that contradict one another [4-12]. Others have also studied the BNP precursor, N-terminal pro-B-type natriuretic peptide (NT-proBNP), which has similar characteristics as a biomarker and similarly found contradictory results [10, 13-15]. The gene discussed is NPPB; the disease is myocardial ischemia.