Cite this article as: Moos WH, Faller DV, Glavas IP, Harpp DN, Kanara I, Mavrakis AN, Pernokas J, Pernokas M, Pinkert CA, Powers WR, Sampani K, Steliou K, Vavvas DG, Zamboni RJ, Kodukula K, Chen X (2020) Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs, BioResearch Open Access 9:1, 94–105, DOI: 10.1089/biores.2020.0004. Here, KL is linked to neurodegenerative disease.