APP and Alzheimer disease: Mediates the transfer of phospholipids and cholesterol across cell membranesInhibits Aβ secretion without affecting the activities of α- and β-secretases Plays roles in APP processing, leading to enhanced Aβ secretion Phagocytic Aβ clearance in microglia is reduced in Abca7-/- mice ABCA7 SNPs are relate to the occurrence of AD