Stimulates the efflux of cholesterol and phospholipid to ApoEIncreased ABCA1 levels induced by LXR ligands can increase the secreted Aβ concentration Decreases the influx of Aβ across the BBB Regulates the levels of ApoE and ApoE lipidation ABCA1 rs2422493 (C-477T) polymorphism are associated with increasing AD risk. This evidence concerns the gene APOE and Alzheimer disease.