Moreover, according to Lei et al. [53], caveolin-3 has been shown to exert a cardio-protective function against hyperglycemia-induced cardiac function; furthermore, hyperglycemia-induced excessive PKCβ2 activation reduces caveolin-3 expression and subsequently reduces Akt signaling, detrimentally affecting cardiac remodeling and function. Here, AKT1 is linked to Hyperglycemia.