In a well-established HD mouse model (R6/2 transgenic mice), α-enolase, γ-enolase, creatine kinase, aconitase, voltage-dependent anion channel 1, and Hsp90 were identified as the main carbonylated proteins that potentially contribute to the impairment of energy metabolism and the pathogenesis of HD [173]. Here, VDAC1 is linked to Huntington disease.