BECN1 and hyperlipidemia: Our results showed that the expression of P62 was increased in db/db cardiac tissues and HG+Ole+Pal group compared with those of the control group, whereas exogenous H2S reduced the expression of P62 and increased the expressions of Atg7, Beclin1 and LC3II, which were related to the disruption of autophagy and lysosome bonding in cardiomyocytes under hyper-glycemia and hyperlipidemia.